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Gene Information
Gene Name
SOD1
Organism
Homo sapiens (Human)
Gene Length
154
Protein Names
Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1)
Target Name
superoxide dismutase [cu-zn]
Target Type
NA
Gene Age
645 ( ENSG00000142168 )
Evolutionary Stage
Cellular_organisms
AlphaFoldDB
P00441
Gene Card
SOD1
Uniprot ID
P00441
Pfam
PF00080
In ASD
no
Allosteric Prediction
yes (0.63652606)
Ortholog in Animals
Alpaca_ SOD1 ( ortholog_one2one )
Dog_ SOD1 ( ortholog_one2one )
GuineaPig_ SOD1 ( ortholog_one2one )
Macaque_ SOD1 ( ortholog_one2one )
Mouse_ Sod1 ( ortholog_one2one )
Pig_ SOD1 ( ortholog_one2one )
Rat_ Sod1 ( ortholog_one2one )
Rabbit_ SOD1 ( ortholog_one2one )
Ohnologs
NA
Paralogs
SOD3, CCS
Tissue
NA
Tissue Specificity
NA
Pharmacological Animal Models
0.051949(Chimpanzee);0.001000(Mouse);0.021602(Rat);0.042281(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1AZV
(X-ray
1.90A
)
1BA9
(NMR
-
)
1DSW
(NMR
-
)
1FUN
(X-ray
2.85A
)
1HL4
(X-ray
1.82A
)
1HL5
(X-ray
1.80A
)
1KMG
(NMR
-
)
1L3N
(NMR
-
)
1MFM
(X-ray
1.02A
)
1N18
(X-ray
2.00A
)
1N19
(X-ray
1.86A
)
1OEZ
(X-ray
2.15A
)
1OZT
(X-ray
2.50A
)
1OZU
(X-ray
1.30A
)
1P1V
(X-ray
1.40A
)
1PTZ
(X-ray
1.80A
)
1PU0
(X-ray
1.70A
)
1RK7
(NMR
-
)
1SOS
(X-ray
2.50A
)
1SPD
(X-ray
2.40A
)
1UXL
(X-ray
1.60A
)
1UXM
(X-ray
1.90A
)
2AF2
(NMR
-
)
2C9S
(X-ray
1.24A
)
2C9U
(X-ray
1.24A
)
2C9V
(X-ray
1.07A
)
2GBT
(X-ray
1.70A
)
2GBU
(X-ray
2.00A
)
2GBV
(X-ray
2.00A
)
2LU5
(NMR
-
)
2MP3
(NMR
-
)
2NAM
(NMR
-
)
2NNX
(X-ray
2.30A
)
2R27
(X-ray
2.00A
)
2V0A
(X-ray
1.15A
)
2VR6
(X-ray
1.30A
)
2VR7
(X-ray
1.58A
)
2VR8
(X-ray
1.36A
)
2WKO
(X-ray
1.97A
)
2WYT
(X-ray
1.00A
)
2WYZ
(X-ray
1.70A
)
2WZ0
(X-ray
1.72A
)
2WZ5
(X-ray
1.50A
)
2WZ6
(X-ray
1.55A
)
2XJK
(X-ray
1.45A
)
2XJL
(X-ray
1.55A
)
2ZKW
(X-ray
1.90A
)
2ZKX
(X-ray
2.72A
)
2ZKY
(X-ray
2.40A
)
3CQP
(X-ray
1.95A
)
3CQQ
(X-ray
1.90A
)
3ECU
(X-ray
1.90A
)
3ECV
(X-ray
1.90A
)
3ECW
(X-ray
2.15A
)
3GQF
(X-ray
2.20A
)
3GTV
(X-ray
2.20A
)
3GZO
(X-ray
2.10A
)
3GZP
(X-ray
3.10A
)
3GZQ
(X-ray
1.40A
)
3H2P
(X-ray
1.55A
)
3H2Q
(X-ray
1.85A
)
3HFF
(X-ray
2.20A
)
3K91
(X-ray
1.75A
)
3KH3
(X-ray
3.50A
)
3KH4
(X-ray
3.50A
)
3LTV
(X-ray
2.45A
)
3QQD
(X-ray
1.65A
)
3RE0
(X-ray
2.28A
)
3T5W
(X-ray
1.80A
)
4A7G
(X-ray
1.24A
)
4A7Q
(X-ray
1.22A
)
4A7S
(X-ray
1.06A
)
4A7T
(X-ray
1.45A
)
4A7U
(X-ray
0.98A
)
4A7V
(X-ray
1.00A
)
4B3E
(X-ray
2.15A
)
4BCY
(X-ray
1.27A
)
4BCZ
(X-ray
1.93A
)
4BD4
(X-ray
2.78A
)
4FF9
(X-ray
2.50A
)
4MCM
(X-ray
2.20A
)
4MCN
(X-ray
2.60A
)
4NIN
(X-ray
1.40A
)
4NIO
(X-ray
1.30A
)
4NIP
(X-ray
1.90A
)
4OH2
(X-ray
2.38A
)
4XCR
(X-ray
3.60A
)
5DLI
(X-ray
2.10A
)
5IIW
(X-ray
2.00A
)
5J07
(X-ray
2.00A
)
5J0C
(X-ray
1.60A
)
5J0F
(X-ray
1.25A
)
5J0G
(X-ray
2.50A
)
5K02
(X-ray
1.99A
)
5O3Y
(X-ray
1.30A
)
5O40
(X-ray
1.50A
)
5U9M
(X-ray
2.35A
)
5WMJ
(X-ray
1.40A
)
5WOR
(X-ray
2.77A
)
5YTO
(X-ray
1.90A
)
5YTU
(X-ray
1.90A
)
5YUL
(X-ray
1.90A
)
6A9O
(X-ray
2.50A
)
6B79
(X-ray
1.80A
)
6DTK
(X-ray
2.00A
)
6FFK
(X-ray
1.94A
)
6FLH
(X-ray
1.79A
)
6FOI
(X-ray
2.00A
)
6FOL
(X-ray
2.55A
)
6FON
(X-ray
3.05A
)
6FP6
(X-ray
3.00A
)
6SPA
(X-ray
1.65A
)
6SPH
(X-ray
2.25A
)
6SPI
(X-ray
2.80A
)
6SPJ
(X-ray
1.97A
)
6SPK
(X-ray
2.77A
)
6Z3V
(X-ray
1.25A
)
6Z4G
(X-ray
1.45A
)
6Z4H
(X-ray
1.95A
)
6Z4I
(X-ray
1.60A
)
6Z4J
(X-ray
1.55A
)
6Z4K
(X-ray
1.45A
)
6Z4L
(X-ray
1.60A
)
6Z4M
(X-ray
1.55A
)
6Z4O
(X-ray
1.40A
)
7CJV
(NMR
-
)
7CJW
(NMR
-
)
7VZF
(EM
2.95A
)
DBSNP
rs121912444
rs121912444
rs121912442
rs121912448
rs1568807330
rs1568807342
rs1568807333
rs121912456
rs1202989817
rs1568807400
rs121912453
rs1555836169
rs1568807435
rs121912450
rs1169198442
rs121912431
rs1555836520
rs121912432
rs121912434
rs121912433
rs121912435
rs121912457
rs121912443
rs1568809175
rs1568809172
rs1568809178
rs986277034
rs1568810275
rs1568810289
rs1568810289
rs121912455
rs1601157750
rs1315541036
rs121912452
rs121912436
rs11556620
rs1339283341
rs1568810660
rs1280042397
rs80265967
rs80265967
rs121912438
rs121912437
rs121912438
rs121912437
rs121912438
rs1568810690
rs1555836806
rs121912439
rs76731700
rs1568810721
rs1568810715
rs121912445
rs1378590183
rs121912440
rs1359299834
rs1601158483
rs1299542356
rs74315452
rs121912441
rs1568810789
rs1301635320
rs1235629842
rs1568811366
rs1568811366
rs1568811372
rs121912454
rs1568811423
rs121912451
rs1804449
rs1482760341
rs121912446
rs121912447
rs1568811515
rs1568811520
rs1476760624
rs567511139
rs1424014997
rs121912449
Subcellular location [CC]
Cytoplasm {ECO:0000269|PubMed:19741096}. Mitochondrion {ECO:0000269|PubMed:19741096}. Nucleus {ECO:0000269|PubMed:22496122}. Note=Predominantly cytoplasmic;
the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria. {ECO:0000269|PubMed:19741096}.
Mouse PG classification
HPG
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