| Gene Information | |
|---|---|
| Gene Name | PFN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 140 |
| Protein Names | Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I) |
| Target Name | profilin-1 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000108518 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P07737 |
| Gene Card | PFN1 |
| Uniprot ID | P07737 |
| Pfam | PF00235 |
| In ASD | no |
| Allosteric Prediction | yes (0.246750913) |
| Ortholog in Animals | Alpaca_ PFN1 ( ortholog_one2one ) GuineaPig_ PFN1 ( ortholog_one2one ) Macaque_ PFN1 ( ortholog_one2one ) Mouse_ Pfn1 ( ortholog_one2one ) Rat_ Pfn1 ( ortholog_one2one ) Rabbit_ PFN1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PFN2, PFN3 |
| Tissue | NA |
| Tissue Specificity | Expressed in epididymis (at protein level). {ECO:0000269|PubMed:20736409}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1AWI (X-ray 2.20A ) 1CF0 (X-ray 2.20A ) 1CJF (X-ray 2.30A ) 1FIK (X-ray 2.30A ) 1FIL (X-ray 2.00A ) 1PFL (NMR - ) 2PAV (X-ray 1.80A ) 2PBD (X-ray 1.50A ) 3CHW (X-ray 2.30A ) 4X1L (X-ray 2.16A ) 4X1M (X-ray 2.17A ) 4X25 (X-ray 2.23A ) 6NAS (X-ray 2.90A ) 6NBE (X-ray 2.00A ) 6NBW (X-ray 2.50A ) 7P1H (EM 3.90A ) |
| DBSNP | rs387907264 rs387907265 rs140547520 rs387907266 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton. |
| Mouse PG classification | LPG |
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