| Gene Information | |
|---|---|
| Gene Name | SOCS6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 581 |
| Protein Names | Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000170677 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O14512 |
| Gene Card | SOCS7 |
| Uniprot ID | O14512 |
| Pfam | PF00017; PF07525 |
| In ASD | no |
| Allosteric Prediction | no (-0.355696093) |
| Ortholog in Animals | Alpaca_ SOCS6 ( ortholog_one2one ) Dog_ SOCS6 ( ortholog_one2one ) GuineaPig_ SOCS6 ( ortholog_one2one ) Macaque_ SOCS6 ( ortholog_one2one ) Mouse_ Socs6 ( ortholog_one2one ) Pig_ SOCS6 ( ortholog_one2one ) Rat_ Socs6 ( ortholog_one2one ) Rabbit_ SOCS6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CISH, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOCS1 |
| Tissue | NA |
| Tissue Specificity | Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain. {ECO:0000269|PubMed:9344857}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence. |
| Mouse PG classification | NA |
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