| Gene Information | |
|---|---|
| Gene Name | SOCS3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 225 |
| Protein Names | Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000184557 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O14543 |
| Gene Card | SOCS3 |
| Uniprot ID | O14543 |
| Pfam | PF00017 |
| In ASD | no |
| Allosteric Prediction | yes (0.182129341) |
| Ortholog in Animals | Alpaca_ SOCS3 ( ortholog_one2one ) Dog_ SOCS3 ( ortholog_one2one ) GuineaPig_ SOCS3 ( ortholog_one2one ) Macaque_ SOCS3 ( ortholog_one2one ) Mouse_ Socs3 ( ortholog_one2one ) Pig_ SOCS3 ( ortholog_one2one ) Rat_ Socs3 ( ortholog_one2one ) |
| Ohnologs | SOCS1 |
| Paralogs | CISH, SOCS6, SOCS2, SOCS4, SOCS5, SOCS7, SOCS1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs1061489 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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