| Gene Information | |
|---|---|
| Gene Name | SOCS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 211 |
| Protein Names | Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000185338 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O15524 |
| Gene Card | SOCS1 |
| Uniprot ID | O15524 |
| Pfam | PF00017 |
| In ASD | no |
| Allosteric Prediction | yes (0.258633802) |
| Ortholog in Animals | Alpaca_ SOCS1 ( ortholog_one2one ) GuineaPig_ SOCS1 ( ortholog_one2one ) Macaque_ SOCS1 ( ortholog_one2one ) Mouse_ Socs1 ( ortholog_one2one ) Pig_ SOCS1 ( ortholog_one2one ) Rat_ Socs1 ( ortholog_one2one ) |
| Ohnologs | SOCS3 |
| Paralogs | CISH, SOCS6, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7 |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs11549428 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:16410555}. Cytoplasmic vesicle {ECO:0000269|PubMed:16410555}. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3. |
| Mouse PG classification | NA |
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