| Gene Information | |
|---|---|
| Gene Name | LRRC8B |
| Organism | Homo sapiens (Human) |
| Gene Length | 803 |
| Protein Names | Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000197147 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q6P9F7 |
| Gene Card | LRRC8B |
| Uniprot ID | Q6P9F7 |
| Pfam | PF13306; PF13855; PF12534 |
| In ASD | no |
| Allosteric Prediction | no (-1.058063542) |
| Ortholog in Animals | Alpaca_ LRRC8B ( ortholog_one2one ) Dog_ LRRC8B ( ortholog_one2one ) GuineaPig_ LRRC8B ( ortholog_one2one ) Macaque_ LRRC8B ( ortholog_one2one ) Mouse_ Lrrc8b ( ortholog_one2one ) Pig_ LRRC8B ( ortholog_one2one ) Rat_ Lrrc8b ( ortholog_one2one ) Rabbit_ LRRC8B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LRRIQ4, LRRC18, LRCH4, LRRK1, LRRC58, LRRD1, PHLPP1, ERBIN, LRRC8C, LRCH2, MFHAS1, SCRIB, LRRC1, LRRC2, PIDD1, LRRC30, LRRC27, LRRC8E, LRRC7, LRCH1, LRRC8A, LRRC8D, LRRC10, LRRC10B, LRRC40, SHOC2, PHLPP2, LRCH3, LRRC69, LRRC39, LRRC28 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17131746 rs17855025 rs3795832 rs12747447 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:24790029}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane. {ECO:0000269|PubMed:24790029}. |
| Mouse PG classification | NA |
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