| Gene Information | |
|---|---|
| Gene Name | SNX6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 406 |
| Protein Names | Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000129515 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9UNH7 |
| Gene Card | SNX6 |
| Uniprot ID | Q9UNH7 |
| Pfam | PF00787; PF09325 |
| In ASD | no |
| Allosteric Prediction | yes (0.13597134) |
| Ortholog in Animals | Alpaca_ SNX6 ( ortholog_one2one ) Dog_ SNX6 ( ortholog_one2many ) GuineaPig_ SNX6 ( ortholog_one2one ) Macaque_ SNX6 ( ortholog_one2one ) Mouse_ Snx6 ( ortholog_one2one ) Pig_ SNX6 ( ortholog_one2one ) Rat_ Snx6 ( ortholog_one2one ) Rabbit_ SNX6 ( ortholog_one2one ) |
| Ohnologs | SNX5, SNX32 |
| Paralogs | SNX5, SNX2, SNX18, SNX7, SNX33, SNX10, SNX4, SNX1, SNX11, SNX12, SNX3, SNX30, SNX8, SNX32, SNX9 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.033713(Chimpanzee);0.021238(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Early endosome {ECO:0000269|PubMed:11485546, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774}. Early endosome membrane {ECO:0000269|PubMed:19935774, ECO:0000303|PubMed:11485546}; Peripheral membrane protein {ECO:0000269|PubMed:11485546}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle {ECO:0000269|PubMed:20354142}. Cytoplasm {ECO:0000269|PubMed:20830743}. Nucleus {ECO:0000269|PubMed:11591366, ECO:0000269|PubMed:20830743}. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes (PubMed:19935774). Only a minor proportion is seen in the nucleus. {ECO:0000269|PubMed:19935774}. |
| Mouse PG classification | NA |
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