| Gene Information | |
|---|---|
| Gene Name | FBXW7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 707 |
| Protein Names | F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000109670 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q969H0 |
| Gene Card | FBXW7 |
| Uniprot ID | Q969H0 |
| Pfam | PF12937; PF00400 |
| In ASD | no |
| Allosteric Prediction | yes (0.387097337) |
| Ortholog in Animals | Alpaca_ FBXW7 ( ortholog_one2one ) Dog_ FBXW7 ( ortholog_one2one ) GuineaPig_ FBXW7 ( ortholog_one2one ) Macaque_ FBXW7 ( ortholog_one2one ) Mouse_ Fbxw7 ( ortholog_one2one ) Pig_ FBXW7 ( ortholog_one2one ) Rat_ Fbxw7 ( ortholog_one2one ) Rabbit_ FBXW7 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FBXW12, FBXW11, WDR49, FBXO36, BTRC, FBXW8, PAAF1, WDR64, EFCAB8, WDR86, FBXO16, TRAF7, FBXW9, WDR54 |
| Tissue | NA |
| Tissue Specificity | [Isoform 1]: Widely expressed. {ECO:0000269|PubMed:12354302}.; [Isoform 3]: Expressed in brain. {ECO:0000269|PubMed:12354302}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001523(Rat);0.021622(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2OVP (X-ray 2.90A ) 2OVQ (X-ray 2.60A ) 2OVR (X-ray 2.50A ) 5IBK (X-ray 2.50A ) 5V4B (X-ray 2.60A ) 7T1Y (X-ray 2.55A ) 7T1Z (X-ray 2.77A ) |
| DBSNP | rs6816935 rs991177157 rs6842544 rs7660281 rs867384286 rs1057519895 rs1057519896 rs7679116 |
| Subcellular location [CC] | [Isoform 1]: Nucleus, nucleoplasm {ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:28007894}. Chromosome {ECO:0000269|PubMed:26774286}. Note=Localizes to site of double-strand breaks following phosphorylation by ATM. {ECO:0000269|PubMed:26774286}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:28007894}.; [Isoform 3]: Nucleus, nucleolus {ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:28007894}. |
| Mouse PG classification | NA |
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