| Gene Information | |
|---|---|
| Gene Name | IL22RA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 263 |
| Protein Names | Interleukin-22 receptor subunit alpha-2 (IL-22 receptor subunit alpha-2) (IL-22R-alpha-2) (IL-22RA2) (Cytokine receptor class-II member 10) (Cytokine receptor family 2 member 10) (CRF2-10) (Cytokine receptor family type 2, soluble 1) (CRF2-S1) (Interleukin-22-binding protein) (IL-22BP) (IL22BP) (ZcytoR16) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000164485 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q969J5 |
| Gene Card | IL22RA2 |
| Uniprot ID | Q969J5 |
| Pfam | PF09294; PF01108 |
| In ASD | no |
| Allosteric Prediction | no (-0.609336936) |
| Ortholog in Animals | Alpaca_ IL22RA2 ( ortholog_one2one ) Dog_ IL22RA2 ( ortholog_one2one ) GuineaPig_ IL22RA2 ( ortholog_one2one ) Macaque_ IL22RA2 ( ortholog_one2one ) Mouse_ Il22ra2 ( ortholog_one2one ) Pig_ IL22RA2 ( ortholog_one2one ) Rat_ Il22ra2 ( ortholog_one2one ) Rabbit_ IL22RA2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IFNAR1, IFNGR2, IL22RA1, F3, IFNLR1, IL10RA, IL20RB, IL20RA, IFNAR2, IFNGR1, IL10RB |
| Tissue | NA |
| Tissue Specificity | Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach. {ECO:0000269|PubMed:11481447, ECO:0000269|PubMed:11607789, ECO:0000269|PubMed:15201862}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.010990(Rat);0.200000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3G9V (X-ray 2.76A ) |
| DBSNP | rs28385692 rs28362173 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:12700595}. |
| Mouse PG classification | NA |
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