| Gene Information | |
|---|---|
| Gene Name | CREM |
| Organism | Homo sapiens (Human) |
| Gene Length | 345 |
| Protein Names | cAMP-responsive element modulator (Inducible cAMP early repressor) (ICER) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000095794 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q03060 |
| Gene Card | CREM |
| Uniprot ID | Q03060 |
| Pfam | PF00170; PF02173 |
| In ASD | no |
| Allosteric Prediction | yes (0.016163592) |
| Ortholog in Animals | Alpaca_ CREM ( ortholog_one2one ) Dog_ CREM ( ortholog_one2one ) GuineaPig_ CREM ( ortholog_one2one ) Macaque_ CREM ( ortholog_one2one ) Mouse_ Crem ( ortholog_one2one ) Rat_ Crem ( ortholog_one2one ) |
| Ohnologs | ATF1, CREB1 |
| Paralogs | CREB3L2, CREB3L3, ATF6, ATF1, ATF6B, CREB3L4, CREB1, CREB3L1, CREB3 |
| Tissue | NA |
| Tissue Specificity | Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes. {ECO:0000269|PubMed:11044457, ECO:0000269|PubMed:14511788, ECO:0000269|PubMed:16143638}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1804604 |
| Subcellular location [CC] | Nucleus.; [Isoform 6]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Mouse PG classification | NA |
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