Gene Information
Gene NameSNX1
OrganismHomo sapiens (Human)
Gene Length522
Protein NamesSorting nexin-1
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000028528 )
Evolutionary StageEukaryota
AlphaFoldDBQ13596
Gene CardSNX1
Uniprot IDQ13596
PfamPF00787; PF03700; PF09325
In ASDno
Allosteric Predictionno (-0.179259561)
Ortholog in AnimalsAlpaca_ SNX1 ( ortholog_one2one )
Dog_ SNX1 ( ortholog_one2one )
GuineaPig_ SNX1 ( ortholog_one2one )
Macaque_ SNX1 ( ortholog_one2one )
Mouse_ Snx1 ( ortholog_one2one )
Pig_ SNX1 ( ortholog_one2one )
Rat_ Snx1 ( ortholog_one2one )
Rabbit_ SNX1 ( ortholog_one2one )
OhnologsSNX2
ParalogsSNX5, SNX6, SNX2, SNX18, SNX7, SNX33, SNX10, SNX4, SNX11, SNX12, SNX3, SNX30, SNX8, SNX32, SNX9
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001407(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2I4K  (NMR  -  )  4FZS  (X-ray  2.80A  ) 
DBSNP rs1049501  rs1802376 
Subcellular location [CC]Endosome membrane {ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:22431521};
Peripheral membrane protein;
Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane {ECO:0000305};
Peripheral membrane protein {ECO:0000305};
Cytoplasmic side {ECO:0000305}. Early endosome membrane;
Peripheral membrane protein;
Cytoplasmic side. Cell projection, lamellipodium {ECO:0000269|PubMed:20604901}. Note=Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:15498486). Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalizes with DNAJC13 and Shiginella dysenteria toxin stxB on early endosomes (PubMed:19874558). Colocalized with F-actin at the leading edge of lamellipodia in a KALRN-dependent manner (PubMed:20604901). {ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:20604901}.
Mouse PG classificationNA
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