| Gene Information | |
|---|---|
| Gene Name | SMARCA5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1052 |
| Protein Names | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) |
| Target Name | swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a member 5 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000153147 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O60264 |
| Gene Card | SMARCA5 |
| Uniprot ID | O60264 |
| Pfam | PF09110; PF00271; PF09111; PF00176 |
| In ASD | yes |
| Allosteric Prediction | yes (0.318956612) |
| Ortholog in Animals | Alpaca_ SMARCA5 ( ortholog_one2one ) Dog_ SMARCA5 ( ortholog_one2one ) GuineaPig_ SMARCA5 ( ortholog_one2one ) Macaque_ SMARCA5 ( ortholog_one2one ) Mouse_ Smarca5 ( ortholog_one2one ) Pig_ SMARCA5 ( ortholog_one2one ) Rat_ Smarca5 ( ortholog_one2many ) Rat_ AABR07028349.1 ( ortholog_one2many ) Rabbit_ SMARCA5 ( ortholog_one2one ) |
| Ohnologs | SMARCA1 |
| Paralogs | SMARCA1, RAD54B, HLTF, HELLS, SHPRH, BTAF1, ZRANB3, TTF2, SMARCA2, CHD9, SMARCAL1, CHD1L, CHD3, RAD54L2, SMARCAD1, CHD4, ATRX, INO80, CHD6, SRCAP, CHD1, CHD2, RAD54L, CHD7, CHD8, EP400, ERCC6, ERCC6L, CHD5, SMARCA4 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001452(Rat);0.023188(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6NE3 (EM 3.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:33092197}. Chromosome {ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:23911928}. Note=Localizes to mitotic chromosomes (PubMed:12972596). Co-localizes with RSF1 in the nucleus (PubMed:12972596). Co-localizes with PCNA at replication foci during S phase (PubMed:15543136). Co-localizes with BAZ1B/WSTF at replication foci during late-S phase (PubMed:15543136). Recruited to DNA damage sites following interactiuon with SIRT6 (PubMed:23911928). {ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:23911928}. |
| Mouse PG classification | NA |
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