| Gene Information | |
|---|---|
| Gene Name | SNTB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 540 |
| Protein Names | Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000168807 ) 3 ( ENSG00000260873 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13425 |
| Gene Card | SNTB2 |
| Uniprot ID | Q13425 |
| Pfam | PF00595; PF18012 |
| In ASD | yes |
| Allosteric Prediction | yes (0.26293705) |
| Ortholog in Animals | Alpaca_ SNTB2 ( ortholog_one2one ) Dog_ SNTB2 ( ortholog_one2one ) GuineaPig_ SNTB2 ( ortholog_one2one ) Macaque_ SNTB2 ( ortholog_one2one ) Mouse_ Sntb2 ( ortholog_one2one ) Pig_ SNTB2 ( ortholog_one2one ) Rat_ Sntb2 ( ortholog_one2one ) Rabbit_ SNTB2 ( ortholog_one2one ) |
| Ohnologs | SNTA1, SNTB1 |
| Paralogs | SNTA1, SNTB1, SNTG2, SNTG1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.019203(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2VRF (X-ray 2.00A ) |
| DBSNP | rs1058482 |
| Subcellular location [CC] | Membrane. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cell junction {ECO:0000250}. Cytoplasm, cytoskeleton. Note=Membrane-associated. In muscle, it is exclusively localized at the neuromuscular junction (By similarity). In insulinoma cell line, it is enriched in secretory granules. {ECO:0000250}. |
| Mouse PG classification | NA |
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