| Gene Information | |
|---|---|
| Gene Name | PDE9A |
| Organism | Homo sapiens (Human) |
| Gene Length | 593 |
| Protein Names | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35) |
| Target Name | phosphodiesterase 9 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000160191 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O76083 |
| Gene Card | PDE9A |
| Uniprot ID | O76083 |
| Pfam | PF00233 |
| In ASD | no |
| Allosteric Prediction | yes (0.479405231) |
| Ortholog in Animals | Alpaca_ PDE9A ( ortholog_one2one ) GuineaPig_ PDE9A ( ortholog_one2one ) Macaque_ PDE9A ( ortholog_one2one ) Mouse_ Pde9a ( ortholog_one2one ) Pig_ PDE9A ( ortholog_one2one ) Rat_ Pde9a ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PDE8A, PDE4A, PDE4D, PDE4B, PDE6A, PDE2A, PDE6C, PDE8B, PDE1B, PDE10A, PDE1A, PDE7A, PDE3B, PDE1C, PDE11A, PDE5A, PDE3A, PDE7B, PDE6B, PDE4C |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood (PubMed:9624146). Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate (PubMed:12565835). In brain, present in the cortex, cerebellum, and subiculum (at protein level) (PubMed:22328573). In heart, primarily localizes to myocytes (PubMed:25799991). {ECO:0000269|PubMed:12565835, ECO:0000269|PubMed:22328573, ECO:0000269|PubMed:25799991, ECO:0000269|PubMed:9624146}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2HD1 (X-ray 2.23A ) 2YY2 (X-ray 2.80A ) 3DY8 (X-ray 2.15A ) 3DYL (X-ray 2.70A ) 3DYN (X-ray 2.10A ) 3DYQ (X-ray 2.50A ) 3DYS (X-ray 2.30A ) 3JSI (X-ray 2.72A ) 3JSW (X-ray 2.30A ) 3K3E (X-ray 2.70A ) 3K3H (X-ray 2.50A ) 3N3Z (X-ray 2.75A ) 3QI3 (X-ray 2.30A ) 3QI4 (X-ray 2.50A ) 4E90 (X-ray 2.50A ) 4G2J (X-ray 2.40A ) 4G2L (X-ray 3.00A ) 4GH6 (X-ray 2.70A ) 4Y86 (X-ray 2.01A ) 4Y87 (X-ray 3.10A ) 4Y8C (X-ray 2.70A ) 6A3N (X-ray 2.60A ) 6LZZ (X-ray 2.40A ) 7F0I (X-ray 2.70A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform PDE9A1]: Cell projection, ruffle membrane {ECO:0000269|PubMed:17090334}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17090334}. Golgi apparatus {ECO:0000269|PubMed:17090334}. Endoplasmic reticulum {ECO:0000269|PubMed:17090334}. Cell membrane, sarcolemma {ECO:0000269|PubMed:25799991}.; [Isoform PDE9A2]: Cell projection, ruffle membrane {ECO:0000269|PubMed:17090334}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17090334}.; [Isoform PDE9A3]: Cytoplasm {ECO:0000269|PubMed:17090334}. Endoplasmic reticulum {ECO:0000269|PubMed:17090334}.; [Isoform PDE9A17]: Cytoplasm {ECO:0000269|PubMed:17090334}. Endoplasmic reticulum {ECO:0000269|PubMed:17090334}. |
| Mouse PG classification | NA |
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