| Gene Information | |
|---|---|
| Gene Name | LAMA5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 3695 |
| Protein Names | Laminin subunit alpha-5 (Laminin-10 subunit alpha) (Laminin-11 subunit alpha) (Laminin-15 subunit alpha) |
| Target Name | laminin subunit alpha-5 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000130702 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | NA |
| Gene Card | LAMA5 |
| Uniprot ID | O15230 |
| Pfam | PF00052; PF00053; PF00054; PF02210; PF06008; PF06009; PF00055 |
| In ASD | no |
| Allosteric Prediction | no (-1.000065472) |
| Ortholog in Animals | GuineaPig_ LAMA5 ( ortholog_one2one ) Mouse_ Lama5 ( ortholog_one2one ) Pig_ LAMA5 ( ortholog_one2one ) Rat_ Lama5 ( ortholog_one2one ) |
| Ohnologs | LAMA3 |
| Paralogs | LAMB2, LAMC3, NTN4, LAMB1, LAMA3, LAMC1, ATRNL1, LAMA2, TMEFF2, ATRN, NTN1, NTN3, LAMC2, TMEFF1, LAMA1, AGRN, LAMB4, NTNG2, NTNG1, LAMA4, MEGF9, MEGF8, LAMB3, EGFLAM, NTN5, USH2A, HSPG2 |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, lung, kidney, skeletal muscle, pancreas, retina and placenta. Little or no expression in brain and liver. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.326396(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5XAU (X-ray 1.80A ) 7CEC (EM 3.90A ) |
| DBSNP | rs4925229 rs6062223 rs3810548 rs2427286 rs17750870 rs13039398 rs944893 rs875379 rs2427284 rs2427283 rs11698080 rs6143021 rs3737137 rs2274934 rs2297587 rs944895 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. |
| Mouse PG classification | NA |
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