| Gene Information | |
|---|---|
| Gene Name | TMEM205 |
| Organism | Homo sapiens (Human) |
| Gene Length | 189 |
| Protein Names | Transmembrane protein 205 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000105518 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q6UW68 |
| Gene Card | TMEM205 |
| Uniprot ID | Q6UW68 |
| Pfam | PF13664 |
| In ASD | no |
| Allosteric Prediction | no (-1.654981782) |
| Ortholog in Animals | Alpaca_ TMEM205 ( ortholog_one2one ) Dog_ TMEM205 ( ortholog_one2one ) GuineaPig_ TMEM205 ( ortholog_one2one ) Macaque_ TMEM205 ( ortholog_one2one ) Mouse_ Tmem205 ( ortholog_one2one ) Pig_ TMEM205 ( ortholog_one2one ) Rat_ Tmem205 ( ortholog_one2one ) Rabbit_ TMEM205 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistant cancer cells (at protein level). {ECO:0000269|PubMed:20589834}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:20589834}; Multi-pass membrane protein {ECO:0000269|PubMed:20589834}. Note=Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance. |
| Mouse PG classification | NA |
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