Gene Information
Gene NameNOSTRIN
OrganismHomo sapiens (Human)
Gene Length506
Protein NamesNostrin (BM247 homolog) (Nitric oxide synthase traffic inducer) (Nitric oxide synthase trafficker) (eNOS-trafficking inducer)
Target NameNA
Target TypeNA
Gene Age886 ( ENSG00000163072 )
3 ( ENSG00000275326 )
Evolutionary StageEukaryota
AlphaFoldDBQ8IVI9
Gene CardNOSTRIN
Uniprot IDQ8IVI9
PfamPF00611; PF14604
In ASDno
Allosteric Predictionno (-0.322607885)
Ortholog in AnimalsAlpaca_ NOSTRIN ( ortholog_one2one )
Dog_ NOSTRIN ( ortholog_one2one )
GuineaPig_ NOSTRIN ( ortholog_one2one )
Macaque_ NOSTRIN ( ortholog_one2one )
Mouse_ Nostrin ( ortholog_one2one )
Pig_ NOSTRIN ( ortholog_one2one )
Rat_ Nostrin ( ortholog_one2one )
Rabbit_ NOSTRIN ( ortholog_one2one )
OhnologsNA
ParalogsCD2AP, SH3D21, SH3KBP1
TissueNA
Tissue SpecificityExpressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level). {ECO:0000269|PubMed:12446846, ECO:0000269|PubMed:15847871}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2YUN  (NMR  -  ) 
DBSNP rs479661 
Subcellular location [CC][Isoform 1]: Cell membrane {ECO:0000269|PubMed:12446846, ECO:0000269|PubMed:16376344};
Peripheral membrane protein {ECO:0000269|PubMed:12446846, ECO:0000269|PubMed:16376344};
Cytoplasmic side {ECO:0000269|PubMed:12446846, ECO:0000269|PubMed:16376344}. Cytoplasmic vesicle {ECO:0000269|PubMed:12446846}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16234328, ECO:0000269|PubMed:16376344}. Note=Enriched in selected actin structures (PubMed:16234328, PubMed:16376344).;
[Isoform 3]: Nucleus {ECO:0000269|PubMed:18980613}.
Mouse PG classificationNA
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