Gene Information
Gene NameSKNY
OrganismHomo sapiens (Human)
Gene Length866
Protein NamesSphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ9NXE4
Gene CardSMPD4
Uniprot IDQ9NXE4
PfamPF14724
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityWidely expressed, with highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:16517606, ECO:0000269|PubMed:18505924, ECO:0000269|PubMed:25180167}.;
[Isoform 1]: Expressed in skeletal muscle (at protein level). {ECO:0000269|PubMed:25180167}.;
[Isoform 2]: Expressed in skeletal muscle but a lower levels than isoform 1 (at protein level). {ECO:0000269|PubMed:25180167}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs747433356  rs1461194496 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000269|PubMed:16517606, ECO:0000269|PubMed:18505924, ECO:0000269|PubMed:31495489};
Single-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:16517606};
Single-pass membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000269|PubMed:31495489}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q6ZPR5}.
Mouse PG classificationNA
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