| Gene Information | |
|---|---|
| Gene Name | SIGLEC12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 595 |
| Protein Names | Sialic acid-binding Ig-like lectin 12 (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 78 ( ENSG00000254521 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q96PQ1 |
| Gene Card | SIGLEC12 |
| Uniprot ID | Q96PQ1 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-0.9031502) |
| Ortholog in Animals | Alpaca_ SIGLEC8 ( ortholog_one2one ) Mouse_ Siglece ( ortholog_one2many ) Rat_ Siglec8 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | MAG, SIGLECL1, CD22, SIGLEC7, SIGLEC9, SIGLEC8, CD33, SIGLEC6, SIGLEC5, SIGLEC14, SIGLEC11, SIGLEC16, SIGLEC10, SIGLEC1, SIGLEC15, TMEM25 |
| Tissue | spleen |
| Tissue Specificity | Isoform Short is highly expressed in spleen, small intestine and adrenal gland; it is lower expressed in thyroid, placenta, brain, stomach, bone marrow, spinal cord and breast. Isoform Long is highly expressed in spleen, small intestine and bone marrow; it is lower expressed in thyroid, placenta, thymus, trachea, stomach, lung, adrenal gland, fetal brain and testis. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2034891 rs2034891 rs3810110 rs6509544 rs6509544 rs11668530 rs3829658 rs3752135 rs57043266 rs7245807 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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