| Gene Information | |
|---|---|
| Gene Name | SLC11A3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 571 |
| Protein Names | Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NP59 |
| Gene Card | SLC40A1 |
| Uniprot ID | Q9NP59 |
| Pfam | PF06963 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in erythrocytes (at protein level). Expressed in placenta, intestine, muscle and spleen. {ECO:0000269|PubMed:10747949, ECO:0000269|PubMed:23219802}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.1(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6W4S (EM 3.20A ) 6WBV (EM 2.50A ) |
| DBSNP | rs1285653301 rs28939076 rs978427853 rs104893673 rs104893662 rs104893662 rs1434101655 rs104893663 rs1397119020 rs104893672 rs104893670 rs11568350 rs104893664 rs368420430 rs104893671 rs11568355 rs45606432 rs1060501102 rs11568346 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10882071, ECO:0000269|PubMed:15692071, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:29237594}; Multi-pass membrane protein {ECO:0000269|PubMed:10882071, ECO:0000269|PubMed:23219802}. Note=Localized to the basolateral membrane of polarized epithelial cells. |
| Mouse PG classification | NA |
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