| Gene Information | |
|---|---|
| Gene Name | SMAD7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 426 |
| Protein Names | Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7) |
| Target Name | mothers against decapentaplegic homolog 7 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000101665 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O15105 |
| Gene Card | SMAD7 |
| Uniprot ID | O15105 |
| Pfam | PF03165; PF03166 |
| In ASD | no |
| Allosteric Prediction | yes (0.737993167) |
| Ortholog in Animals | Alpaca_ SMAD7 ( ortholog_one2one ) Dog_ SMAD7 ( ortholog_one2one ) GuineaPig_ SMAD7 ( ortholog_one2one ) Macaque_ SMAD7 ( ortholog_one2one ) Mouse_ Smad7 ( ortholog_one2one ) Pig_ SMAD7 ( ortholog_one2one ) Rat_ Smad7 ( ortholog_one2one ) Rabbit_ SMAD7 ( ortholog_one2one ) |
| Ohnologs | SMAD6 |
| Paralogs | SMAD6, SMAD2, SMAD3, SMAD5, SMAD4, SMAD1, SMAD9 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous with higher expression in the lung and vascular endothelium. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.007513(Mouse);0.001990(Rat);0.083383(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2DJY (NMR - ) 2KXQ (NMR - ) 2LTV (NMR - ) 2LTW (NMR - ) 2LTX (NMR - ) 2LTY (NMR - ) 2LTZ (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:14657019, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17327236}. Cytoplasm {ECO:0000269|PubMed:14657019, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17327236}. Note=Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:16601693). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). {ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17327236}. |
| Mouse PG classification | NA |
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