Gene Information
Gene NameSNX3
OrganismHomo sapiens (Human)
Gene Length162
Protein NamesSorting nexin-3 (Protein SDP3)
Target Namesorting nexin-3
Target TypeNA
Gene Age1292 ( ENSG00000112335 )
Evolutionary StageEukaryota
AlphaFoldDBO60493
Gene CardSNX3
Uniprot IDO60493
PfamPF00787
In ASDno
Allosteric Predictionno (-0.237208935)
Ortholog in AnimalsAlpaca_ SNX3 ( ortholog_one2one )
Alpaca_ SNX3 ( ortholog_one2many )
Dog_ SNX3 ( ortholog_one2one )
GuineaPig_ SNX3 ( ortholog_one2one )
Macaque_ SNX3 ( ortholog_one2one )
Mouse_ Snx3 ( ortholog_one2one )
Pig_ SNX3 ( ortholog_one2one )
Rat_ Snx3 ( ortholog_one2one )
Rabbit_ SNX3 ( ortholog_one2one )
OhnologsSNX12
ParalogsSNX5, SNX6, SNX2, SNX18, SNX7, SNX33, SNX10, SNX4, SNX1, SNX11, SNX30, SNX8, SNX32, SNX9, SNX12
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2MXC  (NMR  -  )  2YPS  (X-ray  2.60A  )  5F0J  (X-ray  2.70A  )  5F0L  (X-ray  3.20A  )  5F0M  (X-ray  3.10A  )  5F0P  (X-ray  2.78A  )  7BLO  (EM  9.50A  ) 
DBSNP NA 
Subcellular location [CC]Early endosome {ECO:0000269|PubMed:11433298, ECO:0000269|PubMed:21725319, ECO:0000269|PubMed:30213940}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:23237080}. Note=Colocalizes to clathrin-coated endosomal vesicles morphologically distinct from retromer-decorated non-branched endosomal tubule structures (PubMed:21725319) Colocalizes with EEA1 on nascent phagosomes in dendritic cells but competes with EEA1 for binding to phagosomal membrane (PubMed:23237080). In the case of Salmonella enterica infection localizes to Salmonella-containing vacuoles (SCVs) from which SNX3-containing tubules form 30-60 min after infection (PubMed:20482551). {ECO:0000269|PubMed:20482551, ECO:0000269|PubMed:21725319, ECO:0000269|PubMed:23237080}.
Mouse PG classificationNA
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