Gene Information
Gene NameTRPA1
OrganismHomo sapiens (Human)
Gene Length1119
Protein NamesTransient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor)
Target Nametransformation-sensitive protein p120
Target TypeSuccessful target
Gene Age645 ( ENSG00000104321 )
Evolutionary StageEukaryota
AlphaFoldDBO75762
Gene CardTRPA1
Uniprot IDO75762
PfamPF00023; PF12796; PF00520
In ASDyes
Allosteric Predictionyes (1.431525241)
Ortholog in AnimalsAlpaca_ TRPA1 ( ortholog_one2one )
Dog_ TRPA1 ( ortholog_one2one )
GuineaPig_ Trpa1 ( ortholog_one2one )
Macaque_ TRPA1 ( ortholog_one2one )
Mouse_ Trpa1 ( ortholog_one2one )
Pig_ TRPA1 ( ortholog_one2one )
Rat_ Trpa1 ( ortholog_one2one )
Rabbit_ TRPA1 ( ortholog_one2one )
OhnologsNA
ParalogsNA
Tissueurinary.bladder
Tissue SpecificityExpressed at very low levels in fibroblasts. {ECO:0000269|PubMed:10066796}.
Pharmacological Animal Models0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3J9P  (EM  4.24A  )  6HC8  (X-ray  1.90A  )  6PQO  (EM  2.88A  )  6PQP  (EM  3.06A  )  6PQQ  (EM  2.81A  )  6V9V  (EM  2.60A  )  6V9W  (EM  3.10A  )  6V9X  (EM  3.30A  )  6V9Y  (EM  3.60A  )  6WJ5  (EM  3.60A  )  6X2J  (EM  3.00A  )  7JUP  (EM  3.05A  )  7OR0  (EM  2.64A  )  7OR1  (EM  2.64A  ) 
DBSNP rs13268757  rs16937976  rs920829  rs7819749  rs398123010  rs959976 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:20547126, ECO:0000269|PubMed:21873995, ECO:0000269|PubMed:25389312, ECO:0000269|PubMed:25855297};
Multi-pass membrane protein {ECO:0000305}.
Mouse PG classificationNA
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