| Gene Information | |
|---|---|
| Gene Name | SORT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 831 |
| Protein Names | Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000134243 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q99523 |
| Gene Card | SORT1 |
| Uniprot ID | Q99523 |
| Pfam | PF15902; PF15901 |
| In ASD | no |
| Allosteric Prediction | yes (0.180115527) |
| Ortholog in Animals | Alpaca_ SORT1 ( ortholog_one2one ) Dog_ SORT1 ( ortholog_one2one ) GuineaPig_ SORT1 ( ortholog_one2one ) Macaque_ SORT1 ( ortholog_one2one ) Mouse_ Sort1 ( ortholog_one2one ) Pig_ SORT1 ( ortholog_one2one ) Rat_ Sort1 ( ortholog_one2one ) Rabbit_ SORT1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SORL1, SORCS1, SORCS3, SORCS2 |
| Tissue | NA |
| Tissue Specificity | Expressed in brain and prostate (at protein level). Expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta and testis. Expressed at lower levels in lymphoid organs, kidney, colon and liver. {ECO:0000269|PubMed:20048080, ECO:0000269|PubMed:9013611}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.018(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3F6K (X-ray 2.00A ) 3G2U (X-ray 2.30A ) 3G2V (X-ray 2.10A ) 4MSL (X-ray 2.70A ) 4N7E (X-ray 2.70A ) 4PO7 (X-ray 2.66A ) 5MRH (X-ray 2.50A ) 5MRI (X-ray 2.00A ) 6EHO (X-ray 3.50A ) 6X3L (X-ray 2.70A ) 6X48 (X-ray 2.90A ) 6X4H (X-ray 2.90A ) |
| DBSNP | rs2228605 |
| Subcellular location [CC] | Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:16787399, ECO:0000269|PubMed:18817523}; Single-pass type I membrane protein {ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:18817523}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane; Single-pass type I membrane protein; Extracellular side. Lysosome membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Localized to membranes of the endoplasmic reticulum, endosomes, Golgi stack, lysosomes and nucleus. A small fraction of the protein is also localized to the plasma membrane. May also be found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. Localization to the plasma membrane in adipocytes may be enhanced by insulin. |
| Mouse PG classification | NA |
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