| Gene Information | |
|---|---|
| Gene Name | ACVR2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 512 |
| Protein Names | Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB) |
| Target Name | activin receptor type iib |
| Target Type | Literature-reported target |
| Gene Age | 987 ( ENSG00000114739 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13705 |
| Gene Card | ACVR2B |
| Uniprot ID | Q13705 |
| Pfam | PF01064; PF00069 |
| In ASD | no |
| Allosteric Prediction | no (-0.084050775) |
| Ortholog in Animals | Alpaca_ ACVR2B ( ortholog_one2one ) Dog_ ACVR2B ( ortholog_one2one ) GuineaPig_ ACVR2B ( ortholog_one2one ) Macaque_ ACVR2B ( ortholog_one2one ) Mouse_ Acvr2b ( ortholog_one2one ) Pig_ ACVR2B ( ortholog_one2one ) Rat_ Acvr2b ( ortholog_one2one ) |
| Ohnologs | ACVR2A |
| Paralogs | ACVR1, BMPR2, ACVR2A, TGFBR2, TGFBR1, BMPR1A, AMHR2, ACVR1B, BMPR1B, ACVRL1, ACVR1C |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2H62 (X-ray 1.85A ) 2QLU (X-ray 2.00A ) 4FAO (X-ray 3.36A ) 5NGV (X-ray 2.00A ) 5NHR (X-ray 3.35A ) 7MRZ (X-ray 3.00A ) 7OLY (X-ray 3.27A ) |
| DBSNP | rs121434437 rs35882617 rs500611 rs121434438 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:31665064}; Single-pass type I membrane protein {ECO:0000250}. |
| Mouse PG classification | HPG |
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