| Gene Information | |
|---|---|
| Gene Name | KEL |
| Organism | Homo sapiens (Human) |
| Gene Length | 732 |
| Protein Names | Kell blood group glycoprotein (EC 3.4.24.-) (CD antigen CD238) |
| Target Name | kell blood group glycoprotein |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000197993 ) 3 ( ENSG00000276615 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P23276 |
| Gene Card | KEL |
| Uniprot ID | P23276 |
| Pfam | PF01431; PF05649 |
| In ASD | no |
| Allosteric Prediction | no (-0.216948351) |
| Ortholog in Animals | Alpaca_ KEL ( ortholog_one2many ) Dog_ KEL ( ortholog_one2one ) GuineaPig_ KEL ( ortholog_one2one ) Macaque_ KEL ( ortholog_one2one ) Mouse_ Kel ( ortholog_one2one ) Pig_ KEL ( ortholog_one2one ) Rat_ Kel ( ortholog_one2one ) Rabbit_ KEL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MMEL1, PHEX, ECE1, MME, ECE2, ECEL1 |
| Tissue | bone.marrow, testis |
| Tissue Specificity | Expressed at high levels in erythrocytes and testis (in Sertoli cells), and, at lower levels, in skeletal muscle, tonsils (in follicular dendritic cells), lymph node, spleen and appendix (at protein level). Also expressed in many adult and fetal nonerythroid tissues, including brain, spleen, lymph nodes and bone marrow. {ECO:0000269|PubMed:10891471, ECO:0000269|PubMed:11336649}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs8175974 rs61729039 rs8176058 rs61729040 rs61729042 rs61729036 rs8176059 rs61729034 rs61729037 rs61729038 rs61729041 rs61729035 rs61729032 rs61729033 rs8176038 rs8176048 |
| Subcellular location [CC] | Cell membrane; Single-pass type II membrane protein. Note=Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton. |
| Mouse PG classification | NA |
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