| Gene Information | |
|---|---|
| Gene Name | PPFIA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1202 |
| Protein Names | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000131626 ) 3 ( ENSG00000288198 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13136 |
| Gene Card | PPFIA1 |
| Uniprot ID | Q13136 |
| Pfam | PF00536; PF07647 |
| In ASD | no |
| Allosteric Prediction | no (-0.312672303) |
| Ortholog in Animals | Alpaca_ PPFIA1 ( ortholog_one2one ) Dog_ PPFIA1 ( ortholog_one2one ) GuineaPig_ PPFIA1 ( ortholog_one2one ) Macaque_ PPFIA1 ( ortholog_one2one ) Mouse_ Ppfia1 ( ortholog_one2one ) Pig_ PPFIA1 ( ortholog_one2one ) Rat_ Ppfia1 ( ortholog_one2one ) |
| Ohnologs | PPFIA2, PPFIA3 |
| Paralogs | PPFIBP1, PPFIBP2, PPFIA3, PPFIA2, PPFIA4 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:7796809, ECO:0000269|PubMed:9624153}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.034783(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1N7F (X-ray 1.80A ) |
| DBSNP | rs546502 rs11236045 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:7796809}. Note=Colocalizes with PTPRF at the ends of focal adhesions most proximal to the cell nucleus. |
| Mouse PG classification | NA |
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