| Gene Information | |
|---|---|
| Gene Name | SHMT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 504 |
| Protein Names | Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) |
| Target Name | serine hydroxymethyltransferase, mitochondrial |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000182199 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P34897 |
| Gene Card | SHMT2 |
| Uniprot ID | P34897 |
| Pfam | PF00464 |
| In ASD | no |
| Allosteric Prediction | yes (1.284061169) |
| Ortholog in Animals | Alpaca_ SHMT2 ( ortholog_one2one ) Dog_ SHMT2 ( ortholog_one2one ) GuineaPig_ SHMT2 ( ortholog_one2one ) Macaque_ SHMT2 ( ortholog_one2one ) Mouse_ Shmt2 ( ortholog_one2one ) Pig_ SHMT2 ( ortholog_one2one ) Rat_ Shmt2 ( ortholog_one2one ) Rabbit_ SHMT2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SHMT1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.023983(Mouse);0.003490(Rat);0.050000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4PVF (X-ray 2.60A ) 5V7I (X-ray 2.47A ) 5X3V (X-ray 2.85A ) 6DK3 (X-ray 2.04A ) 6H3C (EM 3.90A ) 6M5O (X-ray 2.30A ) 6QVG (X-ray 2.32A ) 6QVL (X-ray 2.28A ) 6R8F (EM 3.80A ) 7BYI (X-ray 2.76A ) |
| DBSNP | rs1426413125 rs2037432429 rs751223752 rs2037448764 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:21876188, ECO:0000269|PubMed:24075985}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:18063578}. Mitochondrion inner membrane {ECO:0000269|PubMed:21876188}. Cytoplasm {ECO:0000269|PubMed:24075985}. Nucleus {ECO:0000269|PubMed:24075985}. Note=Mainly localizes in the mitochondrion. Also found in the cytoplasm and nucleus as part of the BRISC complex (PubMed:24075985). {ECO:0000269|PubMed:24075985}. |
| Mouse PG classification | NA |
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