| Gene Information | |
|---|---|
| Gene Name | SPTA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2419 |
| Protein Names | Spectrin alpha chain, erythrocytic 1 (Erythroid alpha-spectrin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000163554 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P02549 |
| Gene Card | SPTA1 |
| Uniprot ID | P02549 |
| Pfam | PF08726; PF00018; PF00435 |
| In ASD | no |
| Allosteric Prediction | yes (0.588209603) |
| Ortholog in Animals | Alpaca_ SPTA1 ( ortholog_one2one ) Dog_ SPTA1 ( ortholog_one2one ) GuineaPig_ SPTA1 ( ortholog_one2one ) Macaque_ SPTA1 ( ortholog_one2one ) Mouse_ Spta1 ( ortholog_one2one ) Pig_ SPTA1 ( ortholog_one2one ) Rat_ Spta1 ( ortholog_one2one ) Rabbit_ SPTA1 ( ortholog_one2one ) |
| Ohnologs | SPTAN1 |
| Paralogs | DSP, SPTBN5, ACTN4, MICAL2, DMD, SYNE3, GAS2L2, SPTBN2, FLNB, SPTAN1, SYNE2, PLEC, EPPK1, SYNE1, CLMN, DYTN, MICAL3, PKHD1, SMTNL2, DRP2, UTRN, PKHD1L1, ACTN2, ACTN3, MICAL1, SPTBN1, MACF1, ACTN1, DST, SPTB, GAS2L3, FLNC, FLNA, DTNA, DTNB, SPTBN4 |
| Tissue | bone.marrow |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1OWA (NMR - ) 3LBX (X-ray 2.80A ) 5J4O (X-ray 1.54A ) |
| DBSNP | rs121918642 rs121918641 rs121918641 rs121918642 rs773826036 rs201568233 rs121918640 rs121918637 rs121918638 rs121918644 rs121918639 rs3737521 rs199725919 rs16840544 rs121918643 rs121918634 rs121918636 rs121918635 rs12090314 rs11265047 rs7418956 rs7547313 rs35121052 rs34706737 rs35948326 rs2482965 rs34214405 rs863931 rs857725 rs16830483 rs3737515 rs952094 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. |
| Mouse PG classification | HPG |
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