| Gene Information | |
|---|---|
| Gene Name | SLC1A5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 541 |
| Protein Names | Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5) |
| Target Name | alanine/serine/cysteine transporter 2 |
| Target Type | Literature-reported target |
| Gene Age | 645 ( ENSG00000105281 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q15758 |
| Gene Card | SLC1A5 |
| Uniprot ID | Q15758 |
| Pfam | PF00375 |
| In ASD | yes |
| Allosteric Prediction | yes (0.540142174) |
| Ortholog in Animals | Alpaca_ SLC1A5 ( ortholog_one2one ) Dog_ SLC1A5 ( ortholog_one2one ) GuineaPig_ SLC1A5 ( ortholog_one2one ) Macaque_ SLC1A5 ( ortholog_one2one ) Mouse_ Slc1a5 ( ortholog_one2one ) Pig_ SLC1A5 ( ortholog_one2one ) Rat_ Slc1a5 ( ortholog_one2one ) Rabbit_ SLC1A5 ( ortholog_one2one ) |
| Ohnologs | SLC1A4 |
| Paralogs | SLC1A4, SLC1A6, SLC1A2, SLC1A7, SLC1A1, SLC1A3 |
| Tissue | NA |
| Tissue Specificity | Placenta, lung, skeletal muscle, kidney, pancreas, and intestine. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5LLM (X-ray 3.25A ) 5LLU (X-ray 3.32A ) 5LM4 (X-ray 3.10A ) 5MJU (X-ray 3.71A ) 6GCT (EM 3.85A ) 6MP6 (EM 3.54A ) 6MPB (EM 3.84A ) 6RVX (EM 3.61A ) 6RVY (EM 4.13A ) 7BCQ (EM 3.43A ) 7BCS (EM 3.43A ) 7BCT (EM 3.37A ) |
| DBSNP | rs3027956 rs3027961 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:8702519, ECO:0000305|PubMed:29872227}; Multi-pass membrane protein {ECO:0000269|PubMed:29872227}. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Mouse PG classification | NA |
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