| Gene Information | |
|---|---|
| Gene Name | SNCA |
| Organism | Homo sapiens (Human) |
| Gene Length | 140 |
| Protein Names | Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP) |
| Target Name | synuclein alpha |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000145335 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P37840 |
| Gene Card | SNCA |
| Uniprot ID | P37840 |
| Pfam | PF01387 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999883838) |
| Ortholog in Animals | Alpaca_ SNCA ( ortholog_one2one ) Dog_ SNCA ( ortholog_one2one ) GuineaPig_ SNCA ( ortholog_one2one ) Macaque_ SNCA ( ortholog_one2one ) Mouse_ Snca ( ortholog_one2one ) Pig_ SNCA ( ortholog_one2one ) Rat_ Snca ( ortholog_one2one ) Rabbit_ SNCA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SNCB, SNCG |
| Tissue | NA |
| Tissue Specificity | Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain. {ECO:0000269|PubMed:8194594}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1XQ8 (NMR - ) 2JN5 (NMR - ) 2KKW (NMR - ) 2M55 (NMR - ) 2N0A (NMR - ) 2X6M (X-ray 1.62A ) 3Q25 (X-ray 1.90A ) 3Q26 (X-ray 1.54A ) 3Q27 (X-ray 1.30A ) 3Q28 (X-ray 1.60A ) 3Q29 (X-ray 2.30A ) 4BXL (NMR - ) 4R0U (X-ray 1.38A ) 4R0W (X-ray 1.50A ) 4RIK (X-ray 1.85A ) 4RIL (EM 1.43A ) 4ZNN (EM 1.41A ) 5CRW (X-ray 1.60A ) 6A6B (EM 3.07A ) 6CT7 (X-ray 1.90A ) 6CU7 (EM 3.50A ) 6CU8 (EM 3.60A ) 6FLT 6H6B (EM 3.40A ) 6I42 (X-ray 1.38A ) 6L1T (EM 3.22A ) 6L1U (EM 3.37A ) 6L4S (EM 3.37A ) 6LRQ (EM 3.49A ) 6OSJ (EM 2.80A ) 6OSL (EM 3.00A ) 6OSM (EM 3.40A ) 6PEO (EM 3.30A ) 6PES (EM 3.60A ) 6RT0 (EM 3.10A ) 6RTB (EM 3.46A ) 6SST (EM 3.40A ) 6SSX (EM 2.98A ) 6UFR (EM 2.50A ) 6XYO (EM 2.60A ) 6XYP (EM 3.29A ) 6XYQ (EM 3.09A ) 7C1D (EM 3.80A ) 7E0F (EM 3.02A ) 7L7H (EM 4.00A ) 7LC9 (EM 3.20A ) 7NCA (EM 3.47A ) 7NCG (EM 3.43A ) 7NCH (EM 3.84A ) 7NCI (EM 3.55A ) 7NCJ (EM 4.23A ) 7NCK (EM 3.18A ) 7OZG (EM 3.30A ) 7OZH (EM 3.02A ) 7STX (EM 3.14A ) 7V47 (EM 2.80A ) 7V48 (EM 3.00A ) 7V49 (EM 3.40A ) 7V4A (EM 3.20A ) 7V4B (EM 3.10A ) 7V4C (EM 3.30A ) 7V4D (EM 3.50A ) 8A4L (EM 2.68A ) 8A9L (EM 2.16A ) |
| DBSNP | rs104893878 rs104893875 rs201106962 rs104893877 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19762560, ECO:0000269|PubMed:24936070, ECO:0000269|PubMed:25561023, ECO:0000269|PubMed:26442590, ECO:0000269|PubMed:31034892}. Membrane {ECO:0000269|PubMed:24936070}. Nucleus {ECO:0000269|PubMed:12859192, ECO:0000269|PubMed:24936070}. Synapse {ECO:0000269|PubMed:15282274}. Secreted {ECO:0000269|PubMed:24936070}. Cell projection, axon {ECO:0000250|UniProtKB:O55042}. Note=Membrane-bound in dopaminergic neurons (PubMed:15282274). Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at the varicosities (By similarity). {ECO:0000250|UniProtKB:O55042, ECO:0000269|PubMed:15282274}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |