| Gene Information | |
|---|---|
| Gene Name | SLFN12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 578 |
| Protein Names | Ribonuclease SLFN12 (EC 3.1.-.-) (Schlafen family member 12) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 78 ( ENSG00000172123 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q8IYM2 |
| Gene Card | SLFN12 |
| Uniprot ID | Q8IYM2 |
| Pfam | PF04326 |
| In ASD | no |
| Allosteric Prediction | no (-1.021005508) |
| Ortholog in Animals | Alpaca_ SLFN12 ( ortholog_one2many ) Macaque_ SLFN12 ( ortholog_one2one ) Mouse_ Slfn1 ( ortholog_many2many ) Mouse_ Slfn4 ( ortholog_many2many ) Mouse_ Slfn3 ( ortholog_many2many ) Mouse_ Slfn2 ( ortholog_many2many ) Rat_ AC128859.3 ( ortholog_many2many ) Rat_ Slfn4 ( ortholog_many2many ) Rat_ AC118772.2 ( ortholog_many2many ) Rat_ Slfn2 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | SLFN12L, SLFN5, SLFN13, SLFN11, SLFN14, SLFNL1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7EG0 (EM 3.40A ) 7EG1 (EM 3.20A ) 7EG4 (EM 3.20A ) 7LRC (EM 2.97A ) 7LRD (EM 3.22A ) 7LRE (EM 2.76A ) |
| DBSNP | rs1849733 rs2586514 rs12946189 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:35104454}. Cytoplasm, cytosol {ECO:0000269|PubMed:35104454}. |
| Mouse PG classification | NA |
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