Gene Information
Gene NameKIAA0589
OrganismHomo sapiens (Human)
Gene Length668
Protein NamesPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Type I phosphatidylinositol 4-phosphate 5-kinase gamma)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBO60331
Gene CardPIP5K1C
Uniprot IDO60331
PfamPF01504
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue Specificity[Isoform 1]: Isoform 1 is strongly expressed in brain and also detected in heart and lung. {ECO:0000269|PubMed:19548880}.;
[Isoform 2]: Isoform 2 is strongly expressed in pancreas and liver and in lesser quantities in brain, heart, lung and kidney. {ECO:0000269|PubMed:19548880}.;
[Isoform 3]: Isoform 3 is detected in large amounts in heart and large intestine, is also present in lung, pancreas and thyroid, and to a lesser extent in brain, stomach and kidney. {ECO:0000269|PubMed:19548880}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.002240(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2G35  (NMR  -  )  3H1Z  (X-ray  1.83A  )  3H85  (X-ray  2.60A  ) 
DBSNP rs121908315 
Subcellular location [CC]Cell membrane;
Peripheral membrane protein;
Cytoplasmic side {ECO:0000250|UniProtKB:Q5I6B8}. Endomembrane system {ECO:0000250|UniProtKB:Q5I6B8}. Cytoplasm {ECO:0000250|UniProtKB:O70161}. Cell junction, focal adhesion {ECO:0000269|PubMed:12422219}. Cell junction, adherens junction {ECO:0000269|PubMed:17261850}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q5I6B8}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:O70161}. Cell projection, uropodium {ECO:0000250|UniProtKB:O70161}. Note=Detected in plasma membrane invaginations. Isoform 3 is detected in intracellular vesicle-like structures.;
[Isoform 2]: Cytoplasm. Nucleus.
Mouse PG classificationNA
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