| Gene Information | |
|---|---|
| Gene Name | HTR1D |
| Organism | Homo sapiens (Human) |
| Gene Length | 377 |
| Protein Names | 5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin 1D alpha receptor) (5-HT-1D-alpha) (Serotonin receptor 1D) |
| Target Name | 5-hydroxytryptamine receptor 1d |
| Target Type | NA |
| Gene Age | 86 ( ENSG00000179546 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P28221 |
| Gene Card | HTR1D |
| Uniprot ID | P28221 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (0.81988963) |
| Ortholog in Animals | Alpaca_ HTR1D ( ortholog_one2one ) Macaque_ HTR1D ( ortholog_one2one ) |
| Ohnologs | HTR1B, HTR5A, HTR1E, ADRA1D, HTR1F |
| Paralogs | HRH2, TAAR6, DRD4, HRH1, DRD1, GPR52, CHRM3, CHRM4, HRH3, TAAR5, HTR4, TAAR1, GPR21, CHRM1, HRH4, TAAR9, CHRM5, TAAR8, DRD3, GPR84, CHRM2, GPR161, DRD5, TAAR2, HTR1A |
| Tissue | duodenum, small.intestine |
| Tissue Specificity | Detected in brain neocortex and caudate nucleus (at protein level). {ECO:0000269|PubMed:1828434}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7E32 (EM 2.90A ) |
| DBSNP | rs6299 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1652050}; Multi-pass membrane protein {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1652050}. |
| Mouse PG classification | NA |
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