| Gene Information | |
|---|---|
| Gene Name | SMTNL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 494 |
| Protein Names | Smoothelin-like protein 1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000214872 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | A8MU46 |
| Gene Card | SMTNL1 |
| Uniprot ID | A8MU46 |
| Pfam | PF00307 |
| In ASD | no |
| Allosteric Prediction | no (-0.550396909) |
| Ortholog in Animals | Alpaca_ SMTNL1 ( ortholog_one2one ) Dog_ SMTNL1 ( ortholog_one2one ) GuineaPig_ SMTNL1 ( ortholog_one2one ) Macaque_ SMTNL1 ( ortholog_one2one ) Mouse_ Smtnl1 ( ortholog_one2one ) Rat_ Smtnl1 ( ortholog_one2one ) Rabbit_ SMTNL1 ( ortholog_one2one ) |
| Ohnologs | SMTNL2 |
| Paralogs | ASPM, MICALL2, EHBP1L1, EHBP1, MICALL1, GAS2L1, GAS2 |
| Tissue | skeletal.muscle |
| Tissue Specificity | Expressed in striated muscles, specifically in type 2a fibers (at protein level). {ECO:0000269|PubMed:18310078, ECO:0000269|PubMed:20634291}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, myofibril {ECO:0000269|PubMed:18310078}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm (By similarity). Phosphorylation at Ser-301 promotes translocation to the nucleus (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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