| Gene Information | |
|---|---|
| Gene Name | ST6GALNAC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 600 |
| Protein Names | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.3.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (ST6GalNAc-I) (ST6GalNAcI) (hST6GalNAc-I) (Sialyltransferase 7A) (SIAT7-A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000070526 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NSC7 |
| Gene Card | ST6GALNAC1 |
| Uniprot ID | Q9NSC7 |
| Pfam | PF00777 |
| In ASD | no |
| Allosteric Prediction | no (-0.921337957) |
| Ortholog in Animals | Alpaca_ ST6GALNAC1 ( ortholog_one2one ) Dog_ ST6GALNAC1 ( ortholog_one2one ) GuineaPig_ ST6GALNAC1 ( ortholog_one2one ) Macaque_ ST6GALNAC1 ( ortholog_one2one ) Mouse_ St6galnac1 ( ortholog_one2one ) Pig_ ST6GALNAC1 ( ortholog_one2one ) Rat_ St6galnac1 ( ortholog_one2one ) Rabbit_ ST6GALNAC1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ST6GALNAC5, C20orf173, ST3GAL4, ST3GAL3, ST3GAL2, ST6GAL1, ST6GALNAC4, ST6GALNAC3, ST6GALNAC6, ST6GALNAC2, ST3GAL5, ST3GAL6, ST6GAL2, ST3GAL1 |
| Tissue | colon, small.intestine.Peyers.patch, stomach, transverse.colon |
| Tissue Specificity | Expression is restricted to the gastrointestinal tract (PubMed:16319059). Highly expressed in goblet cells (PubMed:35303419). Also expressed in various tumor cells (PubMed:16319059). {ECO:0000269|PubMed:16319059, ECO:0000269|PubMed:35303419}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs8077382 rs146032525 rs548273650 rs35948039 rs150096642 |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000269|PubMed:16319059, ECO:0000269|PubMed:35303419}; Single-pass type II membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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