| Gene Information | |
|---|---|
| Gene Name | DOCK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1830 |
| Protein Names | Dedicator of cytokinesis protein 2 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000134516 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q92608 |
| Gene Card | DOCK2 |
| Uniprot ID | Q92608 |
| Pfam | PF06920; PF20422; PF20421; PF14429; PF16172; PF07653 |
| In ASD | no |
| Allosteric Prediction | no (-0.478004301) |
| Ortholog in Animals | Alpaca_ DOCK2 ( ortholog_one2one ) Dog_ DOCK2 ( ortholog_one2one ) GuineaPig_ DOCK2 ( ortholog_one2one ) Macaque_ DOCK2 ( ortholog_one2one ) Mouse_ Dock2 ( ortholog_one2one ) Pig_ DOCK2 ( ortholog_one2one ) Rat_ AABR07029272.1 ( ortholog_one2one ) |
| Ohnologs | DOCK4, DOCK5, DOCK1 |
| Paralogs | DOCK6, DOCK9, DOCK8, DOCK1, DOCK4, DOCK10, DOCK3, DOCK11, DOCK5, DOCK7 |
| Tissue | spleen, whole.blood |
| Tissue Specificity | Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon. {ECO:0000269|PubMed:10559471}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2RQR (NMR - ) 2YIN (X-ray 2.70A ) 3A98 (X-ray 2.10A ) 3B13 (X-ray 3.01A ) 6TGB (EM 5.50A ) 6TGC (EM 4.10A ) |
| DBSNP | rs1581090174 rs780318765 rs13179480 rs2270898 rs2270898 |
| Subcellular location [CC] | Endomembrane system {ECO:0000269|PubMed:12393632}; Peripheral membrane protein {ECO:0000269|PubMed:12393632}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12393632}. Note=Colocalizes with F-actin. |
| Mouse PG classification | NA |
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