| Gene Information | |
|---|---|
| Gene Name | SLC4A5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1137 |
| Protein Names | Electrogenic sodium bicarbonate cotransporter 4 (NBCe2) (Solute carrier family 4 member 5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000188687 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9BY07 |
| Gene Card | SLC4A5 |
| Uniprot ID | Q9BY07 |
| Pfam | PF07565; PF00955 |
| In ASD | no |
| Allosteric Prediction | no (-0.034732594) |
| Ortholog in Animals | Alpaca_ SLC4A5 ( ortholog_one2one ) Dog_ SLC4A5 ( ortholog_one2one ) GuineaPig_ SLC4A5 ( ortholog_one2one ) Macaque_ SLC4A5 ( ortholog_one2one ) Mouse_ Slc4a5 ( ortholog_one2one ) Pig_ SLC4A5 ( ortholog_one2one ) Rat_ Slc4a5 ( ortholog_one2one ) Rabbit_ SLC4A5 ( ortholog_one2one ) |
| Ohnologs | SLC4A7, SLC4A4, SLC4A9 |
| Paralogs | SLC4A9, SLC4A3, SLC4A2, SLC4A4, SLC4A10, SLC4A11, SLC4A7, SLC4A1, SLC4A8 |
| Tissue | testis, thyroid |
| Tissue Specificity | Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle. {ECO:0000269|PubMed:10978526, ECO:0000269|PubMed:11087115, ECO:0000269|PubMed:17715183, ECO:0000269|PubMed:26447209}.; [Isoform 3]: Expressed in the brain, heart, kidney, testis, pancreas, muscle and peripheral blood leukocytes. {ECO:0000269|PubMed:11788353}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs17009792 rs55651232 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:17715183, ECO:0000269|PubMed:26447209}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q6RI88}; Multi-pass membrane protein {ECO:0000255}. Note=Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla. {ECO:0000269|PubMed:17715183}. |
| Mouse PG classification | NA |
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