| Gene Information | |
|---|---|
| Gene Name | SMO |
| Organism | Homo sapiens (Human) |
| Gene Length | 555 |
| Protein Names | Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1) |
| Target Name | smoothened homolog |
| Target Type | Successful target |
| Gene Age | 886 ( ENSG00000128602 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NWM0 |
| Gene Card | SMOX |
| Uniprot ID | Q9NWM0 |
| Pfam | PF01593 |
| In ASD | yes |
| Allosteric Prediction | yes (0.874710174) |
| Ortholog in Animals | Alpaca_ SMO ( ortholog_one2one ) Alpaca_ SMO ( ortholog_one2many ) Dog_ SMO ( ortholog_one2one ) GuineaPig_ SMO ( ortholog_one2one ) Macaque_ SMO ( ortholog_one2one ) Mouse_ Smo ( ortholog_one2one ) Pig_ SMO ( ortholog_one2one ) Rat_ Smo ( ortholog_one2one ) Rabbit_ SMO ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SFRP5, SFRP1, FZD5, FZD2, FZD10, FZD9, SFRP4, FZD7, FRZB, FZD6, FZD8, FZD1, SFRP2, FZD4, FZD3 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed in human tumor cell lines. Isoform 4 is only found in an embryonal kidney cell line. {ECO:0000269|PubMed:18422650}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7OXL (X-ray 2.40A ) 7OY0 (X-ray 2.09A ) |
| DBSNP | rs6084654 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 4]: Cytoplasm. Nucleus.; [Isoform 6]: Cytoplasm. Nucleus. |
| Mouse PG classification | LPG |
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