| Gene Information | |
|---|---|
| Gene Name | SLC1A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 524 |
| Protein Names | Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Neuronal and epithelial glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1) |
| Target Name | excitatory amino acid transporter 3 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000106688 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P43005 |
| Gene Card | SLC1A1 |
| Uniprot ID | P43005 |
| Pfam | PF00375 |
| In ASD | no |
| Allosteric Prediction | yes (0.104708161) |
| Ortholog in Animals | Alpaca_ SLC1A1 ( ortholog_one2one ) Dog_ SLC1A1 ( ortholog_one2one ) GuineaPig_ SLC1A1 ( ortholog_one2one ) Macaque_ SLC1A1 ( ortholog_one2one ) Mouse_ Slc1a1 ( ortholog_one2one ) Pig_ SLC1A1 ( ortholog_one2one ) Rat_ Slc1a1 ( ortholog_one2one ) |
| Ohnologs | SLC1A6, SLC1A7 |
| Paralogs | SLC1A4, SLC1A6, SLC1A2, SLC1A7, SLC1A5, SLC1A3 |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers). {ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:7859077, ECO:0000269|PubMed:7914198}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6S3Q (EM 3.34A ) 6X2L (EM 2.85A ) 6X2Z (EM 3.03A ) 6X3E (EM 3.42A ) 6X3F (EM 3.03A ) 7NSG (EM 3.34A ) |
| DBSNP | rs2229885 rs2228621 rs587777696 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:21123949, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:7914198, ECO:0000269|PubMed:8857541}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P43003}. Apical cell membrane {ECO:0000269|PubMed:21123949}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P43003}. Synapse, synaptosome {ECO:0000250|UniProtKB:P51906}. Early endosome membrane {ECO:0000250|UniProtKB:P51906}. Late endosome membrane {ECO:0000250|UniProtKB:P51906}. Recycling endosome membrane {ECO:0000250|UniProtKB:P51906}. |
| Mouse PG classification | HPG |
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