| Gene Information | |
|---|---|
| Gene Name | HS3ST1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 307 |
| Protein Names | Heparan sulfate glucosamine 3-O-sulfotransferase 1 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1) (3-OST-1) (Heparan sulfate 3-O-sulfotransferase 1) (h3-OST-1) |
| Target Name | heparan sulfate glucosamine 3-o-sulfotransferase 1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000002587 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O14792 |
| Gene Card | HS3ST1 |
| Uniprot ID | O14792 |
| Pfam | PF00685 |
| In ASD | no |
| Allosteric Prediction | no (-1.320926517) |
| Ortholog in Animals | Alpaca_ HS3ST1 ( ortholog_one2one ) Dog_ HS3ST1 ( ortholog_one2one ) GuineaPig_ HS3ST1 ( ortholog_one2one ) Macaque_ HS3ST1 ( ortholog_one2one ) Mouse_ Hs3st1 ( ortholog_one2one ) Pig_ HS3ST1 ( ortholog_one2one ) Rat_ Hs3st1 ( ortholog_one2one ) Rabbit_ HS3ST1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HS3ST3A1, NDST1, HS3ST4, HS3ST2, NDST3, HS3ST6, NDST4, NDST2, HS3ST3B1, HS3ST5 |
| Tissue | ovary, gall.bladder, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Highly expressed in the brain and kidney and weakly expressed in the heart, lung and placenta. {ECO:0000269|PubMed:9988767}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ZRH (X-ray 2.10A ) |
| DBSNP | rs11559238 rs34719057 |
| Subcellular location [CC] | Golgi apparatus lumen {ECO:0000305}. |
| Mouse PG classification | NA |
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