| Gene Information | |
|---|---|
| Gene Name | SMIF |
| Organism | Homo sapiens (Human) |
| Gene Length | 582 |
| Protein Names | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NPI6 |
| Gene Card | DCP1A |
| Uniprot ID | Q9NPI6 |
| Pfam | PF06058; PF16741 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas. {ECO:0000269|PubMed:11836524}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.007652(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2WX3 (X-ray 2.31A ) 4B6H (X-ray 2.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, P-body {ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:12515382, ECO:0000269|PubMed:16364915}. Nucleus {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715}. Note=Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB) (PubMed:16364915). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (PubMed:11836524). {ECO:0000250|UniProtKB:Q91YD3, ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:16364915}. |
| Mouse PG classification | NA |
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