| Gene Information | |
|---|---|
| Gene Name | ITGA4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1032 |
| Protein Names | Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d) |
| Target Name | integrin alpha-4 |
| Target Type | Successful target |
| Gene Age | 987 ( ENSG00000115232 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P13612 |
| Gene Card | ITGA4 |
| Uniprot ID | P13612 |
| Pfam | PF01839; PF08441 |
| In ASD | no |
| Allosteric Prediction | yes (0.868451232) |
| Ortholog in Animals | Alpaca_ ITGA4 ( ortholog_one2one ) Dog_ ITGA4 ( ortholog_one2one ) GuineaPig_ ITGA4 ( ortholog_one2one ) Macaque_ ITGA4 ( ortholog_one2one ) Mouse_ Itga4 ( ortholog_one2one ) Pig_ ITGA4 ( ortholog_one2one ) Rat_ Itga4 ( ortholog_one2one ) Rabbit_ ITGA4 ( ortholog_one2one ) |
| Ohnologs | ITGA9 |
| Paralogs | ITGA10, ITGAX, ITGAE, ITGA2, ITGAD, ITGA5, ITGA6, ITGAV, ITGA7, ITGA8, ITGAL, ITGA3, ITGA2B, ITGA11, ITGA1, ITGAM, ITGA9 |
| Tissue | spleen |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003490(Rat);0.044444(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 3V4P (X-ray 3.15A ) 3V4V (X-ray 3.10A ) 4HKC (X-ray 2.20A ) 5C7Z (X-ray 2.77A ) 5FPI (X-ray 2.77A ) |
| DBSNP | rs35322532 rs1143675 rs1143676 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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