| Gene Information | |
|---|---|
| Gene Name | SMCR8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 937 |
| Protein Names | Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000176994 ) 3 ( ENSG00000283741 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q8TEV9 |
| Gene Card | SMCR8 |
| Uniprot ID | Q8TEV9 |
| Pfam | PF11704 |
| In ASD | no |
| Allosteric Prediction | no (-1.251799048) |
| Ortholog in Animals | Alpaca_ SMCR8 ( ortholog_one2one ) Dog_ SMCR8 ( ortholog_one2one ) GuineaPig_ SMCR8 ( ortholog_one2one ) Macaque_ SMCR8 ( ortholog_one2one ) Mouse_ Smcr8 ( ortholog_one2one ) Pig_ SMCR8 ( ortholog_one2one ) Rat_ Smcr8 ( ortholog_one2one ) Rabbit_ SMCR8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues tested. {ECO:0000269|PubMed:11997338}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.007657(Rat);0.050000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6LT0 (EM 3.20A ) 6V4U (EM 3.80A ) 7EL6 (X-ray 2.80A ) 7MGE (EM 3.94A ) 7O2W (EM - ) |
| DBSNP | rs8080966 rs1563632 rs12449313 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:28195531}. Nucleus {ECO:0000269|PubMed:28195531}. Presynapse {ECO:0000250|UniProtKB:Q3UMB5}. Postsynapse {ECO:0000250|UniProtKB:Q3UMB5}. Note=Localizes mainly in the cytoplasm. {ECO:0000269|PubMed:28195531}. |
| Mouse PG classification | NA |
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