| Gene Information | |
|---|---|
| Gene Name | MMP13 |
| Organism | Homo sapiens (Human) |
| Gene Length | 471 |
| Protein Names | Collagenase 3 (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13) |
| Target Name | matrix metalloproteinase-13 |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000137745 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P45452 |
| Gene Card | MMP13 |
| Uniprot ID | P45452 |
| Pfam | PF00045; PF00413; PF01471 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000355822) |
| Ortholog in Animals | Alpaca_ MMP13 ( ortholog_one2one ) Dog_ MMP13 ( ortholog_one2one ) GuineaPig_ MMP13 ( ortholog_one2one ) Macaque_ MMP13 ( ortholog_one2one ) Mouse_ Mmp13 ( ortholog_one2one ) Pig_ MMP13 ( ortholog_one2one ) Rat_ Mmp13 ( ortholog_one2one ) Rabbit_ MMP13 ( ortholog_one2one ) |
| Ohnologs | MMP25, MMP2, MMP11, MMP15, MMP17, MMP16 |
| Paralogs | MMP24, MMP16, MMP21, MMP14, MMP2, MMP1, MMP19, MMP23B, MMP10, MMP9, MMP12, MMP15, MMP27, MMP17, MMP25, MMP28, MMP7, MMP20, MMP26, HPX, MMP8, MMP3, MMP11 |
| Tissue | bone.marrow |
| Tissue Specificity | Detected in fetal cartilage and calvaria, in chondrocytes of hypertrophic cartilage in vertebrae and in the dorsal end of ribs undergoing ossification, as well as in osteoblasts and periosteal cells below the inner periosteal region of ossified ribs. Detected in chondrocytes from in joint cartilage that have been treated with TNF and IL1B, but not in untreated chondrocytes. Detected in T lymphocytes. Detected in breast carcinoma tissue. {ECO:0000269|PubMed:8207000, ECO:0000269|PubMed:8798568, ECO:0000269|PubMed:9056642, ECO:0000269|PubMed:9562863}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1EUB (NMR - ) 1FLS (NMR - ) 1FM1 (NMR - ) 1PEX (X-ray 2.70A ) 1XUC (X-ray 1.70A ) 1XUD (X-ray 1.80A ) 1XUR (X-ray 1.85A ) 1YOU (X-ray 2.30A ) 1ZTQ (X-ray 2.00A ) 2D1N (X-ray 2.37A ) 2E2D (X-ray 2.00A ) 2OW9 (X-ray 1.74A ) 2OZR (X-ray 2.30A ) 2PJT (X-ray 2.80A ) 2YIG (X-ray 1.70A ) 3ELM (X-ray 1.90A ) 3I7G (X-ray 1.95A ) 3I7I (X-ray 2.21A ) 3KEC (X-ray 2.05A ) 3KEJ (X-ray 2.30A ) 3KEK (X-ray 1.97A ) 3KRY (X-ray 1.90A ) 3LJZ (X-ray 2.00A ) 3O2X (X-ray 1.90A ) 3TVC (X-ray 2.43A ) 3WV1 (X-ray 1.98A ) 3WV2 (X-ray 2.30A ) 3WV3 (X-ray 1.60A ) 3ZXH (X-ray 1.30A ) 456C (X-ray 2.40A ) 4A7B (X-ray 2.20A ) 4FU4 (X-ray 2.85A ) 4FVL (X-ray 2.44A ) 4G0D (X-ray 2.54A ) 4JP4 (X-ray 1.43A ) 4JPA (X-ray 2.00A ) 4L19 (X-ray 1.66A ) 5B5O (X-ray 1.20A ) 5B5P (X-ray 1.60A ) 5BOT (X-ray 1.85A ) 5BOY (X-ray 2.03A ) 5BPA (X-ray 1.79A ) 5UWK (X-ray 1.60A ) 5UWL (X-ray 2.55A ) 5UWM (X-ray 1.62A ) 5UWN (X-ray 3.20A ) 7JU8 (X-ray 2.00A ) 830C (X-ray 1.60A ) |
| DBSNP | rs554797 rs121909498 rs121909497 rs121909499 rs140059558 rs121909500 rs17860568 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:8576151}. Secreted {ECO:0000269|PubMed:8576151}. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |