| Gene Information | |
|---|---|
| Gene Name | SMC4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1288 |
| Protein Names | Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000113810 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9NTJ3 |
| Gene Card | SMC4 |
| Uniprot ID | Q9NTJ3 |
| Pfam | PF06470; PF02463 |
| In ASD | no |
| Allosteric Prediction | yes (0.356692558) |
| Ortholog in Animals | Alpaca_ SMC4 ( ortholog_one2one ) Dog_ SMC4 ( ortholog_one2one ) GuineaPig_ SMC4 ( ortholog_one2one ) Macaque_ SMC4 ( ortholog_one2one ) Mouse_ Smc4 ( ortholog_one2one ) Pig_ SMC4 ( ortholog_one2one ) Rat_ Smc4 ( ortholog_one2one ) Rabbit_ SMC4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SMC1B, SMC3, CCDC157, CKAP4, SMC2, SMC1A, CCDC122 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Higher expression in testis, colon, thymus. {ECO:0000269|PubMed:10319587}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4U4P (X-ray 1.89A ) |
| DBSNP | rs35214835 rs33999879 rs2164675 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10958694}. Cytoplasm {ECO:0000269|PubMed:10958694}. Chromosome {ECO:0000269|PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase. |
| Mouse PG classification | NA |
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