| Gene Information | |
|---|---|
| Gene Name | SMC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1217 |
| Protein Names | Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000108055 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9UQE7 |
| Gene Card | SMC3 |
| Uniprot ID | Q9UQE7 |
| Pfam | PF06470; PF02463 |
| In ASD | no |
| Allosteric Prediction | yes (0.225756383) |
| Ortholog in Animals | Alpaca_ SMC3 ( ortholog_one2one ) Dog_ SMC3 ( ortholog_one2one ) GuineaPig_ SMC3 ( ortholog_one2one ) Macaque_ SMC3 ( ortholog_one2one ) Mouse_ Smc3 ( ortholog_one2one ) Pig_ SMC3 ( ortholog_one2one ) Rat_ Smc3 ( ortholog_one2one ) Rabbit_ SMC3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SMC1B, SMC4, CCDC157, CKAP4, SMC2, SMC1A, CCDC122 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.116264(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6WG3 (EM 5.30A ) 6WG4 (X-ray 2.31A ) 6WG6 (X-ray 3.54A ) 6WGE (EM 3.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q9CW03}. Chromosome {ECO:0000250|UniProtKB:Q9CW03}. Chromosome, centromere {ECO:0000250|UniProtKB:Q9CW03}. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. The phosphorylated form at Ser-1083 is preferentially associated with unsynapsed chromosomal regions (By similarity). {ECO:0000250|UniProtKB:Q9CW03}. |
| Mouse PG classification | LPG |
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