| Gene Information | |
|---|---|
| Gene Name | SMC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1197 |
| Protein Names | Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome-associated protein E) (hCAP-E) (XCAP-E homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000136824 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O95347 |
| Gene Card | SMC2 |
| Uniprot ID | O95347 |
| Pfam | PF06470; PF02463 |
| In ASD | no |
| Allosteric Prediction | no (-0.0116026) |
| Ortholog in Animals | Alpaca_ SMC2 ( ortholog_one2one ) Dog_ SMC2 ( ortholog_one2one ) GuineaPig_ SMC2 ( ortholog_one2one ) Macaque_ SMC2 ( ortholog_one2one ) Mouse_ Smc2 ( ortholog_one2one ) Pig_ SMC2 ( ortholog_one2one ) Rat_ Smc2 ( ortholog_one2one ) Rabbit_ SMC2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SMC1B, SMC3, SMC4, CCDC157, CKAP4, SMC1A, CCDC122 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.010650(Mouse);0.003490(Rat);0.045455(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4U4P (X-ray 1.89A ) |
| DBSNP | rs4562395 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10958694}. Cytoplasm {ECO:0000269|PubMed:10958694}. Chromosome {ECO:0000269|PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase. |
| Mouse PG classification | NA |
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