| Gene Information | |
|---|---|
| Gene Name | SMARCAL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 954 |
| Protein Names | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000138375 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NZC9 |
| Gene Card | SMARCAL1 |
| Uniprot ID | Q9NZC9 |
| Pfam | PF07443; PF00271; PF00176 |
| In ASD | no |
| Allosteric Prediction | no (-1.157101931) |
| Ortholog in Animals | Alpaca_ SMARCAL1 ( ortholog_one2one ) Dog_ SMARCAL1 ( ortholog_one2one ) GuineaPig_ SMARCAL1 ( ortholog_one2one ) Macaque_ SMARCAL1 ( ortholog_one2one ) Mouse_ Smarcal1 ( ortholog_one2one ) Pig_ SMARCAL1 ( ortholog_one2one ) Rat_ Smarcal1 ( ortholog_one2one ) Rabbit_ SMARCAL1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SMARCA1, RAD54B, HLTF, HELLS, SHPRH, BTAF1, ZRANB3, SMARCA5, TTF2, SMARCA2, CHD9, CHD1L, CHD3, RAD54L2, SMARCAD1, CHD4, ATRX, INO80, CHD6, SRCAP, CHD1, CHD2, RAD54L, CHD7, CHD8, EP400, ERCC6, ERCC6L, CHD5, SMARCA4 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, with high levels in testis. {ECO:0000269|PubMed:10857751, ECO:0000269|PubMed:11799392}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001823(Rat);0.046154(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4MQV (X-ray 1.95A ) |
| DBSNP | rs17851400 rs2066524 rs11555797 rs6734114 rs2066522 rs2066518 rs2066520 rs119473036 rs119473038 rs1313658611 rs119473037 rs2066523 rs200644381 rs2271336 rs267607071 rs200666300 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:19793862, ECO:0000269|PubMed:19793863}. Note=Recruited to damaged DNA regions. |
| Mouse PG classification | NA |
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