Gene Information
Gene NameSPACA3
OrganismHomo sapiens (Human)
Gene Length215
Protein NamesSperm acrosome membrane-associated protein 3 (Cancer/testis antigen 54) (CT54) (Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17) (Lysozyme-like protein 3) (Sperm lysozyme-like protein 1) (Sperm protein reactive with antisperm antibodies) (Sperm protein reactive with ASA) [Cleaved into: Sperm acrosome membrane-associated protein 3, membrane form; Sperm acrosome membrane-associated protein 3, processed form]
Target NameNA
Target TypeNA
Gene Age332 ( ENSG00000141316 )
Evolutionary StageEumetazoa
AlphaFoldDBQ8IXA5
Gene CardSPACA3
Uniprot IDQ8IXA5
PfamPF00062
In ASDno
Allosteric Predictionno (-0.805064804)
Ortholog in AnimalsAlpaca_ SPACA3 ( ortholog_one2one )
Dog_ SPACA3 ( ortholog_one2one )
GuineaPig_ SPACA3 ( ortholog_one2one )
Macaque_ SPACA3 ( ortholog_one2one )
Mouse_ Spaca3 ( ortholog_one2one )
Pig_ SPACA3 ( ortholog_one2one )
Rat_ Spaca3 ( ortholog_one2one )
Rabbit_ SPACA3 ( ortholog_one2one )
OhnologsSPACA5B, LYZ, LYZL4
ParalogsLYZ, LYZL2, LYZL1, LYZL6, SPACA5B, SPACA5, LALBA, LYZL4
Tissuetestis, pancreas
Tissue SpecificityThe processed form is expressed in sperm (at protein level). Expressed in testis, epididymis and placenta. {ECO:0000269|PubMed:12606493, ECO:0000269|PubMed:16014814}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs16967845  rs28963  rs35420663 
Subcellular location [CC][Isoform 1]: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000305};
Single-pass type II membrane protein {ECO:0000305}. Note=Anterior acrosome in non-capacitated spermatozoa and retained in the equatorial segment and in the luminal face of both the inner and outer acrosomal membranes following capacitation and the acrosome reaction. {ECO:0000250}.;
[Isoform 2]: Secreted {ECO:0000305}.
Mouse PG classificationNA
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